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Markata is a great python framework that allows you to go from markdown to a full website very quickly. You can get up and running with nothing more than Markdown. It is also built on a full plugin architecture, so if there is extra functionality that you want to add, you can create a plugin to make it behave like you want.
Full transparancy... I built markata.
The talk is live on YouTube. Make sure you check out the other videos from the conference. There were quite a few quality talks that deserve a watch as well.