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The prefix key is an essential part of tmux, by default all of tmux's key-bindings sit behind a prefix. This prefix is very similar to vim's leader key. It is common for folks to change the default C-b (control b) to C-a or if they are a vim user something to match their vim leader key.

set -g prefix C-Space
bind Space send-prefix

A few of the essential default key-bindings.

%      vertical split
"      horizontal split
d      detach

up select up one pane down select down one pane right select right one pane left select left one pane

t clock o swap panes c create window n next window p previous window

A more complete list of key-bindings can be found in this gist https://gist.github.com/mzmonsour/8791835.

[[ tmux-nav-2021 ]]

for more information on how I navigate tmux, check out this full post